{
  "provenance": {
    "data_source": "TEAS_EA_RECONCILED_MASTER_DATA_v26_FINAL_LOCK_READY.xlsx",
    "statistical_source": "StataNow 19.5 BE - 06_FINAL_ANALYSIS_V26/02_STATA/01_opioid24_primary.do",
    "prospero": "CRD420251090635",
    "cohort": "v26 strict primary 24-h opioid set (inc_primary==1), k=6, N=628",
    "conversion_note": "Sufentanil converted at 1000:1 (1.0 mg IV MME per ug) per the corrected prespecified framework; see 06_AUDIT/opioid_conversion_audit.csv."
  },
  "k": 6,
  "studies": [
    {
      "study_id": "1879896688",
      "study_key": "Chen 2020",
      "citation": "Chen J, et al. *Thorac Cancer*. 2020;11(4):928-934. DOI: 10.1111/1759-7714.13343",
      "modality": "TEAS",
      "comparator": "Sham",
      "opioid_timepoint": "0-24 h",
      "opioid_md_mme": -28.19,
      "opioid_unit": "mg IV MME",
      "pain_timepoint": "~24 h",
      "pain_md_vas": -0.65,
      "pain_scale": "VAS (0-10)",
      "result_rob_opioid_24h": "Some concerns",
      "paired_inclusion_status": "Included (v26 strict primary paired cohort)"
    },
    {
      "study_id": "1879897506",
      "study_key": "Chen 1998",
      "citation": "Chen L, et al. *Anesth Analg*. 1998;87(5):1129-1134. DOI: 10.1097/00000539-199811000-00028",
      "modality": "TEAS",
      "comparator": "Sham",
      "opioid_timepoint": "0-24 h",
      "opioid_md_mme": -21,
      "opioid_unit": "mg IV MME",
      "pain_timepoint": "~24 h",
      "pain_md_vas": -0.8,
      "pain_scale": "VAS (0-10)",
      "result_rob_opioid_24h": "Some concerns",
      "paired_inclusion_status": "Included (v26 strict primary paired cohort)"
    },
    {
      "study_id": "1879896891",
      "study_key": "Seevaunnamtum 2016",
      "citation": "Praveena Seevaunnamtum S, et al. *Anesth Pain Med*. 2016;6(6):e40106. DOI: 10.5812/aapm.40106. PMID: 28975075",
      "modality": "EA",
      "comparator": "Usual Care",
      "opioid_timepoint": "0-24 h",
      "opioid_md_mme": -12.56,
      "opioid_unit": "mg IV MME",
      "pain_timepoint": "~24 h",
      "pain_md_vas": -0.03,
      "pain_scale": "VAS (0-10)",
      "result_rob_opioid_24h": "Some concerns",
      "paired_inclusion_status": "Included (v26 strict primary paired cohort)"
    },
    {
      "study_id": "1879897344",
      "study_key": "El-Rakshy 2009",
      "citation": "El-Rakshy M, et al. *Acupunct Med*. 2009;27(1):9-12. DOI: 10.1136/aim.2008.000075",
      "modality": "EA",
      "comparator": "Usual Care",
      "opioid_timepoint": "0-24 h",
      "opioid_md_mme": -1.6,
      "opioid_unit": "mg IV MME",
      "pain_timepoint": "~24 h",
      "pain_md_vas": -0.4,
      "pain_scale": "VAS (0-10)",
      "result_rob_opioid_24h": "High",
      "paired_inclusion_status": "Included (v26 strict primary paired cohort)"
    },
    {
      "study_id": "1879895909",
      "study_key": "He 2026 (hepatectomy/JIS)",
      "citation": "He S, et al. *J Invest Surg*. 2026;39(1):2653912. DOI: 10.1080/08941939.2026.2653912",
      "modality": "TEAS",
      "comparator": "Sham",
      "opioid_timepoint": "0-24 h",
      "opioid_md_mme": -0.6,
      "opioid_unit": "mg IV MME",
      "pain_timepoint": "~24 h",
      "pain_md_vas": -0.2,
      "pain_scale": "VAS (0-10)",
      "result_rob_opioid_24h": "Some concerns",
      "paired_inclusion_status": "Included (v26 strict primary paired cohort)"
    },
    {
      "study_id": "1879896323",
      "study_key": "Yang 2024",
      "citation": "Yang J, et al. *Explore (NY)*. 2024;20(3):450-455. DOI: 10.1016/j.explore.2023.11.004. PMID: 38007308",
      "modality": "EA",
      "comparator": "Usual Care",
      "opioid_timepoint": "0-24 h",
      "opioid_md_mme": -0.3,
      "opioid_unit": "mg IV MME",
      "pain_timepoint": "~24 h",
      "pain_md_vas": -0.15,
      "pain_scale": "VAS (0-10)",
      "result_rob_opioid_24h": "Some concerns",
      "paired_inclusion_status": "Included (v26 strict primary paired cohort)"
    }
  ]
}